The latest issue of Nature on the recession provides analysis and advice on the global economic downturn. Science is key to nation-building during a recession but scientists must learn to convince politicians of the need to protect research budgets. But building global links and breaking down the barriers between disciplines is also vital if the world is to weather the financial squeeze. Central banks must end their obsession with cutting interest rates and technology start-ups will need to cut costs and sell what they can. A stimulus package for the developing world could, however, benefit everyone.